OpenPyXL

import openpyxl

## Workbook
wb = openpyxl.load_workbook('sample.xlsx')
wb = openpyxl.Workbook()
wb.save('sample.xlsx')
wb.sheetnames

## Worksheet
ws = wb['Sheet']
ws = wb.worksheets[0]
ws.title

## Cell A1
c1 = ws['A1']
c1 = ws.cell(1, 1)
c1.coordinate
c1.row
c1.column
c1.value = 100

## Cell A2
c2 = ws['A2']
c2 = ws.cell(2, 1)
c2.value = "=SUM(A1:A1)"

## Region
r1 = ws['A1:C3']

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